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2007 [cited 2025 Apr 19];21(3):11330

Mechanistically, DM-induced perturbations in the AMPK/mTOR signaling axis, impaired branched-chain amino acid catabolism, and tryptophan-kynurenine axis dysregulation collectively drive oxidative stress and immune homeostasis disruption through cascade reactions, culminating in pulmonary parenchymal injury

10.1016/j.ejcb.2015.05.002 [DOI] [PubMed] [Google Scholar] Lin W, Paterson GA, Zhu Q, Wang Y, Kopylova E, Li Y, Knight R, Bazylinski DA, Zhu R, Kirschvink JL, & Pan Y (2017)

Circadian disturbances are not likely to be an epiphenomenon of bipolar illness given that they are present during mania, depression, in euthymic state, and in healthy relatives of bipolar patients (181, 182)