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10.1007/s00428-005-1264-9 48 DongZ.WangJ

R 3 and R 4 are independently selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, and C1-C12 substituted alkynyl, or optionally R 3 and R 4 together are bonded to form a fused bicyclic ring system or a spirocyclic ring system, where the fused ring is a C3-C8 heterocycloalkyl or C 6 - C10 aryl or C4-C10 heteroaryl

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Proc Natl Acad Sci USA 114:52895294 Marschner P (2012) Marschners mineral nutrition of higher plants, 3rd edn

Growing evidence indicates that acute or chronic liver injury is strongly associated with gut microorganisms, and the importance of gut-liver interaction has been increasingly emphasized [5]