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These changes, along with mitochondrial architectural modifications like the disappearance of cristae and swollen epithelium of the bronchi, were associated with upregulated oxidative stress and inflammation, ultimately contributing to the pathogenesis of asthma in the 12/15-LOX OE mice [40] (Figure 3)

Life Basel 11(4):304

Furthermore, the dual role of NRF2as a protective factor in early liver disease and a promoter of tumor survival in advanced stagesposes a therapeutic dilemma