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doi: 10.1007/s00203-021-02584-0 11 BlintA.FarkasK.MhiO.KintsesB.VsrhelyiB

(Boyle's law) Anesthesia planning Avoid morphine if possible (histamine release) Consider Ketamine Consider Propofol Avoid Etomidate (increased airway resistance and adrenal dysfunction) Consider paralytics Succinlcholine Rocuronium Cisatracurium Glucocorticoids Prednisone 40 mg Methylprednisolone 60 mg or (0.5-1 mg/kg q6 hrs to a max of 60 mg/day pediatric) Dexamethasone Consider use of empiric antimicrobials (azithromycin)

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The overall structure shows that ORF3a forms a dimer with the ion channel decorated with charged residues for cation conduction (Fig