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Results GSH synthesis is required for the survival of adult animals To better understand the importance of GSH in adult mammals, we developed an inducible, whole-body Gclc KO mouse by breeding the Gclc f/f mouse strain 30 with the Rosa26-CreERT2 mouse strain 31

Of note, partial activation of Akt boosts the activation of mTORC2, which phosphorylates and ultimately activates Akt, resulting in a positive feedback loop [35] (Fig