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In order to maintain the osteogenic differentiation ability of MSCs, RNA modification, long non-coding RNA regulation, and DNA damage repair are particularly important

In fact, hypoxia and hypoglycaemia lead to an alteration of the metabolism of the nerve cell, to the extent of depleting (exhausting) the energy reserves (basically, the ATP) and causing the malfunctioning of the mitochondria, with the disorder of the cytochromes and the partial reduction of oxygen

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These reducing equivalents subsequently donate electrons to the electron transport chain (ETC), leading to hyperpolarization of the mitochondrial membrane potential