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The catalytic mechanism of GSTZs differs from other GSTs in that GSH is initially conjugated to the cis double bond of maleylacetoacetate allowing the isomerisation reaction, before being eliminated in a second step allowing the formation of fumarylacetoacetate (Thom et al., 2001)

Kalvelyte A, Imbrasaite A, Bukauskiene A, Verselis VK, Bukauskas FF

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Glutathione, on the other hand, reduces H 2 O 2 to H 2 O by providing additional electrons

In addition, the BBB poses a significant challenge to the successful implementation of immunotherapy for stroke due to its highly selective nature