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doi: 10.1158/0008-5472.CAN-13-1641

Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V (2014) Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

The fatty acids consumed by the model group were more than four times that of the control group

During this process, tumor cells undergo a transformation from an epithelial phenotype to a more aggressive mesenchymal phenotype, enhancing the ability to evade the effects of the drug and promote survival

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to regularly evaluate renal function