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Ibuprofen causes stomach irritation and bleeding, while acetaminophen poses a higher risk of liver damage if taken in excess.

Although the same effects have not yet been verified in humans, a study in mice showed that extreme restriction of both carbohydrates and protein should be avoided because of potential development of fatty liver Non-alcoholic-Fatty Liver-Disease (NAFLD) or even worse, progression of the fatty liver to actual liver damage as is seen in Non-alcoholic Steatohepatitis (NASH)

JPEN 2014

Insulin treatment remains a significant but complex aspect of managing type 2 diabetes

The bottom line for most of us is that we dont need to take supplements of these B vitamins