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Volcano plot screening showed that the ribosomal protein RPL15 significantly decreased after GGT knockout

The addition of a C-terminal Pro-Gly-Pro extension to the tuftsin core dramatically improved metabolic stability, allowing the peptide to survive intranasal delivery long enough to exert meaningful neurobiological effects

Science 379 , 10231030 (2023)

A comparison of activities revealed that compound 3f was significantly more active than the latter two mentioned above

Risks include thyroid C-cell tumors (contraindicated with personal/family MTC or MEN2)496903084605990312L22-L26, pancreatitis, gallbladder disease, and hypoglycemia when combined with insulin496903084605990312L206-L209