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These include: 2-hydroxybutyric acid, linked to oxidative stress and insulin resistance Methylsuccinic, tricarballylic, and orotic acids, often tied to microbial imbalance or urea cycle problems Various keto and hydroxy acids such as 2-oxo-4-methiolbutyric acid, 3-methylglutaric acid, and 3-oxoglutaric acid, which may reflect sulfur metabolism, mitochondrial overload, or B-vitamin deficiency When interpreted in context, these markers help identify blocks or imbalances in methylation-related pathways

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Rivard, R

[DOI] [PubMed] [Google Scholar] 80.Serrat MA