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For the most part, humanized antibodies are human immunoglobulins (recipient antibody) in which residues from a hypervariable region (also CDR) of the recipient are replaced by residues from a hypervariable region of a non- human (e.g., rodent) species (donor antibody) such as mouse, rat, hamster or rabbit having the desired specificity, affinity, and capacity

These molecules can pass through the BBB by means of their specific transporters, such as GLUT1, LAT-1/CAT-1, and CNT2, respectively, in the direction of the concentration gradient (Pardridge, 2003

Always ensure that the mixture you inject is appropriately diluted

This neuroprotection is mediated by the activation of antioxidant enzyme systems, attenuation of inflammatory mediator levels, suppression of apoptotic pathways, enhancement of autophagy, and other related mechanisms (Figure 4 and Table 2)