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However, blocking lysosomal delivery of PGRN by knocking out sortilin significantly increases PGRN and decreases granulin levels in mouse brain lysates, suggesting that the PGRN processing occurs predominantly in the lysosome in the mouse brain [104, 105] (Fig

These antioxidants fight oxidative damage through different mechanisms

Funding The publication was supported in Debrecen by the GINOP-2.3.2-15-2016-00062 project (IP) co-financed by the European Union and the regional Development Fund