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The liver uses this same system in bile acid synthesis and the hydroxylation of cholecalciferol to 25-hydroxycholecalciferol (vitamin D3;), and the kidney uses it to hydroxylate vitamin D3 to its biologically active 1,25-dihydroxylated form

, 1992), and neurodevelopment (Truman et al

All steps in these machineries are evolutionarily conserved from yeast to man

Some neonatal studies show no depletion at therapeutic doses, suggesting babies may metabolize it differently

En cualquier caso, siempre hay que tener en mente que un suplemento, independientemente del tipo que sea, no puede plantearse nunca como un sustitutivo de una alimentacin equilibrada