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Collectively, these approaches offer novel mechanistic insights and therapeutic avenues for targeting ferroptosis propagation in the AD brain

This ultimately reduces oxidative stress and prevents skin photoaging (Figure 4)

134,135 IL-1 inhibition IL-1 is a cytokine that has the capability of immune and pro-inflammatory actions

(1988) Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer

However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)