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[89] collected urine samples over a 24-hr period and found at rest there was no significant change in urine output at rest when consuming water or varying doses of caffeine in the range of 114 mg/d-253 mg/d (1.4 mg/kg - 3.13 mg/kg)

Reported side effects include water retention, flushing, headache, tingling in the extremities, elevated IGF-1 levels, impaired glucose tolerance, and injection site reactions including pain and infection risk

A cooperative role of NRF2 and C/EBP (a transcription factor of the CCAAT/enhancer binding protein family) was described in generating tumor-specific enhancers that promote tumor initiation via NOTCH3 activation (Okazaki et al, 2020)

It is clear that ferroptosis has an intimate relationship with pathological cell death

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