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Extended IDPs are characterized by a turned out response to heat and changes in pH, where high temperatures or extreme pH values induce their partial folding (Uversky, 2009)

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Diabetologia 58 , 3136 (2015)

The marked increases in the incidences of autism, asthma, and attention deficit disorder in the United States coincide with the replacement of aspirin by acetaminophen in the 1980s