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Studies have examined its effects on tendon-to-bone healing, ligament repair, and collagen organisation in pre-clinical injury models making it a central compound for laboratories studying connective tissue regeneration

The 13-amino-acid N-terminal extension (sequence MFPAMPLLSLFVN) shifts the three-dimensional conformation of the binding interface, while the Arg 3 Glu 3 substitution disrupts a key contact residue with IGFBPs

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doi: 10.1038/s41522-025-00779-7, 98 MigniniI.GalassoL.PiccirilliG.CalvezV.TermiteF.EspostoG.et al