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Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]

Van den Bossche, L.A

This results in the precocious appearance of cells at the bottom of the colon crypts, which are engaged in differentiating into MUC2-expressing goblet cells

Acknowledgments As a previous Clinical Director of Psychiatry at the Queen Elizabeth Hospital, Woodville SA., Dr Jrg Strobel, MD (Bonn)

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