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doi: 10.1016/j.ijpara.2015.03.004 108 CassCLJohnsonJRCaliffLLXuTHernandezHJStadeckerMJet al

The degeneration of neurons producing dopamine in the substantia nigra leads to a depletion of dopamine within the striatum, disrupting the finely tuned excitatory and inhibitory signaling in the basal ganglia