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Animals All mice were maintained under specific pathogen-free conditions at the Prklinisches Experimentelles Tierzentrum (PETZ), Erlangen, Germany and approved by the local ethics authorities of the Regierung of Unterfranken (#55.2-2532-2-424 and #55.2-2532-2-630)

Neurol 77, 146153 (2015)

Based on the copper content measurements, all recombinantly produced proteins ( jr PPO1-wt and five mutants) contain a similar amount of copper (~0.81.1 copper ions per protein), indicating that the changes in activity are not based on the number of copper ions in the active center