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As specifically demonstrated in recent studies on FXN -deficient DRG neurons and patient fibroblasts, treatment with omaveloxolone successfully drives the upregulation of Nrf2 and the GPx4 enzymatic shield

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At this pressure, more oxygen enters the blood and is delivered to tissues in need

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142 Additionally, inhibition of COX17 leads to elevated mitochondrial copper levels in leukemic stem cells, which results in reduced cellular levels of S-adenosylmethionine, subsequently decreasing global DNA methylation and increasing chromatin accessibility, which contributes to promoting the differentiation of acute myeloid leukemia cells while reducing stem cell-like characteristics