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All crown ethers have a central cavity that can accommodate a metal ion coordinated to the ring of oxygen atoms., cyclic compounds with the general formula (OCH 2 CH 2 ) n

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OH), H 2 O 2 , nitrogen dioxide (NO) and peroxynitrite (ONOO ), these deriving mainly from the mitochondrial electron transport chain, changes in metal valence states and enzymatic processes (e.g., MAO-B, NADPH oxidase) (45)