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Smedley and Kinniburgh 2002

thus, GSH depletion ultimately leads to increased lipid peroxidation 23

Similarly, female rats exposed to trauma exhibited increased abundance of Anaerovorax and Flavonifractor , latter being associated with GABA disruption (Tanelian et al., 2023)

Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T