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Drug Saf 26(3):187195 Gompels MM, Simpson N, Snow M, Spickett G, Ong E (1999) Desensitization to co-trimoxazole (trimethoprim-sulphamethoxazole) in HIV-infected patients: is patch testing a useful predictor of reaction

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They are most intense during the first few weeks at each dose level and typically improve as the body adapts

NAD+ injections' impact on intracellular and compartmental NAD+ pools, however, is not yet known (1)