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This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation (Galluzzi et al., 2018)

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Cell 133 , 452461 (2008)

Collectively, these studies reinforce the versatility of CQDs, however comprehensive in vivo assessments of BBB transport, biodistribution, and long-term neurotoxicity are still required to substantiate clinical translational potential