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Graphical Abstract Similar content being viewed by others Introduction Alzheimers disease (AD) is a progressive neurodegenerative disease that currently lacks effective treatment options, which poses a considerable challenge to the global modern healthcare system [1]

Stimulation of NK1 receptors on the endothelium causes vasodilatation mediated by NO

Peer review Peer review information Nature Reviews Materials thanks Jae-Won Shin and Daniela Traini, who co-reviewed with Jerry Wong, for their contribution to the peer review of this work

Bristols nivolumab (Opdivo) is a distant second with about $10B/year

This suggests that VA-ECMO has no significant impact on the exposure of levosimendan