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The positive anti-tumor effects of SAHA notwithstanding, it is crucial to highlight the elevated toxicity observed with high doses of the drug, resulting in adverse effects like fatigue, diarrhea, anorexia, dehydration, myelosuppression, thrombocytopenia, among others (Mrakovcic et al., 2017)

CGI-C of much improved or very much improved was achieved in 26% of patients on placebo, 28% receiving 12 mg/day, 49% receiving 24 mg/day, and 44% on 36 mg/day