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37,38 These agents have serotonergic and noradrenergic activity, as well as -opioid binding, so they have some effect on descending antinociceptive central pathways

The future likely involves both drugs coexisting as options for different patient profiles, similar to how semaglutide and tirzepatide both have their place in current practice

doi: 10.1016/S0196-9781(99)00025-X 135 AsarianLGearyN

Although probiotic supplementation is considered to be safe, long-term probiotic administration in infants or immunocompromised people requires special consideration