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For instance, elevated glycolysis-induced lactylation of SRY-related high mobility group-box 9 (SOX9), a transcription factor belonging to the SOX family, promotes stemness, migration, and invasion of NSCLC cells

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bioRxiv 134 SugiuraA.MattieS.PrudentJ.McBrideH

In the overall odevixibat-treated group, 29 of 63 (46%) patients with data at week 72 met serum bile acid response criteria

Th17 cells depend on FAS for membrane biosynthesis and inflammatory signaling, requiring enzymes such as acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FASN) (99)