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Simultaneously, in the extracellular pathway, drugs penetrate the nasal epithelium and enter the lamina propria, then move along the perineural spaces surrounding olfactory and trigeminal axons, allowing both small and large molecules to reach the CNS

Furthermore, toxic proteins present in Crotonis Fructus (Badou), such as croton protein I and II, not only exert direct cytotoxicity by inhibiting protein synthesis but also induce hemolysis by damaging erythrocyte membranes [61, 62]

In particular, the relevance of the ATB 0,+ -mediated carnitine transport, in patients with PCD, may be explained considering that this protein is highly expressed in the intestine (Figure 2)

Under normoxic conditions, the proline residue of HIF1 is hydroxylated

A role for glutamine synthetase in the remobilization of leaf nitrogen during natural senescence in rice leaves