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doi: 10.1016/j.apsb.2021.08.016 [DOI] [PMC free article] [PubMed] [Google Scholar] 94.Castelli G, Logozzi M, Mizzoni D, et al

If symptoms suggest deficiency but serum B12 looks normal, ask for a methylmalonic acid (MMA) test it detects cellular deficiency earlier

Eur J Biochem 156:569577 Britsch L, Heller W, Grisebach H (1981) Conversion of flavanone to flavone, dihydroflavonol and flavonol with an enzyme system from cell cultures of parsley

In line with that, several compounds with NRF2-inducing activity, such as sulforaphane, the anti-epileptic drug dyclonine, DMF, N-acetyl cysteine, and omaveloxolone among others, showed beneficial effects and frataxin-inducing activity in different models of FRDA (Petrillo et al., 2017