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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)

Taken together with our metabolomic profiling of L-cystine starved cells (Fig

Setting aside the economic impact of IBD, the individual suffering brought about by these diseases is immeasurable

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