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The Phase IIb clinical trials failed because AOD 9604 did not produce a statistically significant amount of weight loss in obese patients compared to a placebo

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Although primarily known for its tanning properties, Melanotan II has also shown promise in weight loss

It was a pivotal trial, the kind of study that determines whether a drug moves forward toward regulatory approval

Briefly, 1 mM stock solution of each compound was prepared in deionized water, diluted to a final concentration of 400 M in PBS (Sigma Aldrich