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doi: 10.1210/jc.2013-2376 [DOI] [PMC free article] [PubMed] [Google Scholar] 23.Darmaun D, Welch S, Smith S, Sweeten S, Mauras N

In the case of eNOS uncoupling due to relative intracellular BH 4 deficiency, this phenomenon could be prevented by simultaneous overexpression of the BH 4 synthesizing enzyme GTP cyclohydrolase I, which has been demonstrated in isolated cells 92 and in atherosclerotic animal models