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Furthermore, there is more and more evidence for a crucial role of N-chlorination in the modulation of host protein function to amplify and sustain host immune responses to infection and inflammation

Glucose-6-phosphate dehydrogenase deficiency pathophysiology Editor-In-Chief: C

At the receptor level, MK-677 binds the growth hormone secretagogue receptor 1a (GHS-R1a) on somatotroph cells of the anterior pituitary and on hypothalamic neurons, mimicking the orexigenic peptide ghrelin

10.1186/s12905-022-02154-6 329 SunP.YuC.YinL.ChenY.SunZ.ZhangT.et al (2024)

Many of these VUS are synonymous or non-coding variants that may affect RNA abundance or isoform but cannot be prioritized due to the poor understanding of regulatory sequence to date compared to coding sequence