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Additionally, capecitabine is well known to cause hand-foot syndrome (palmar-plantar erythrodysesthesia) , which, although classified dermatologically, shares mechanistic overlap with GI toxicity due to the drugs activation in high perfusion areas

Further to this, some mice were fed on a diet that had the effect of inhibiting protein-arginine deiminase 4 (involved in NET formation), or metoprolol (involved in neutrophil migration)

Seek urgent care if you experience severe symptoms, blood glucose above 300 mg/dL, or signs of infection

Nat Med 19 , 533534 (2013)