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I.Diaz-CollierJ.SaundersC.et al (1986)

However, current variants of roGFPs are largely inadequate in mutants with very low glutathione levels, generally oxidizing conditions like in the ER, or oxidizing conditions triggered by pathological processes

While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments