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Finally, CS signaling should be viewed as an integrated network rather than as autonomous linear pathways

doi: 10.1016/j.biochi.2016.10.019

A few ingredients can treat and prevent dark spots, including vitamin C, niacinamide, ferulic acid, glutathione, AHAs (like glycolic and lactic acid), retinol and its alternatives, and Japanese rice bran

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In wild-type cells, we observed a strong oxidation of the cytosolic NADP pool upon treatment with 2 and 5 mM diamide ( Figure 5B )