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Moving forward, the integration of cutting-edge technologies such as multi-omics approaches, advanced imaging techniques, and computational modeling will be pivotal in unraveling these complexities

This is because it is a sensitive molecule that is not located in a controlled environment within the cell, as is the case with most enzymes, but functions outside the cell and is thus exposed to various disruptive influences

doi: 10.1016/s0006-291x(02)02741-9 634 DuJKleinJDHassounahFZhangJZhangCWangXH

NRF2 also regulates the removal of damaged and misfolded proteins through the regulation of the proteasome

This situation is reflected by the large metabolic rate of neurons and by the comparatively higher sensitivity of brain tissues to oxygen and glucose deprivation