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While this observation theoretically might be explained by a larger increase of ADP despite an increase of ATP, a mechanistic explanation how both ATP and ADP increases simultaneously within minutes is lacking, suggesting that these observations might rather be due to technical differences compared to the experiments performed with the ATeam-type of GEMIs, which report the concentration of ATP

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Nature Reviews Cancer, 9 (6), 429439

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This further confirms that the enhancement of Nrf2 is a viable strategy for activating the GSH system

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