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This was due to the BMD 100 critical effect sizes being calculated at a less variable part of the concentrationresponse curve which, in turn, provides a clearer comparison between the NAs

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However, ADH is considerably more sensitive to small changes in osmolality than changes in blood volume: a 1% decrease of plasma osmolality stimulates ADH secretion, whereas a 10% decrease in blood volume is necessary to clearly increase ADH levels ( Guyton and Hall 2006 )

Heres another interesting case: Two adolescent patients suffering from persistent sleep-wake schedule disorders appear to have responded to treatment with vitamin B12 (methylcobalamin)