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Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses

Itaconate, a mitochondria-derived immunometabolite, is significantly downregulated in patients with active SLE, and the loss of its antioxidant protection may contribute to disease activity [62]

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Four types of neutrophil granules have been identified, including specific granules, gelatinase granules, azurophilic, and secretory vesicles, with the azurophilic granules posing the greatest threat to phagocytic bacteria