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In studies using human fetal fibroblast cultures, Epithalon treatment extended cellular proliferative potential from termination at the 34th passage in control populations to beyond the 44th passage in treated cells, effectively surpassing the Hayflick limitthe maximum number of divisions normal cells can undergo before senescence

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In adult tissues, this pathway has been implicated in regeneration and wound healing (Chmielowiec et al., 2007

These receptors, like the lipoprotein receptor related protein (LRP-1), normally allow essential substances like glucose, insulin and growth hormones to enter the brain