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Klar AS, Biedermann T, Michalak K, Michalczyk T, Meuli-Simmen C, Scherberich A, Meuli M, Reichmann E

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doi: 10.1007/s12011-019-02017-6 25

9 Acquired 5FU resistance is associated with increased mitochondrial content and signaling

Therefore, the deletion of the GDH2 gene will certainly impact on the catabolism of arginine and proline, considering that Gdh2 is the main enzyme capable of converting glutamate into -ketoglutarate through the reduction of NAD +