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doi: 10.1007/s13167-011-0123-9

The inflammatory response leads to increased permeability of the endothelial lining, influx of blood leukocytes into the interstitial space, an oxidative burst, and the release of cytokines

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Thus, the immune regulatory role of SUA functions as a double-edged sword, with its effectswhether inhibition or activationdependent on the inflammatory nature of the local microenvironment (aseptic or infectious), the intensity of stimulation, and the cell-specific metabolic pathways influenced by SUA

This aspect was reflected in our model