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Neuropathol Appl Neurobiol

G4251, Sigma Aldrich, Milan, Italy), GR (4 U/10 mL buffer, cat.G3664, Sigma Aldrich, Milan, Italy), NADPH (cat

In response, the brain activates the microglia which undergo morphological changes, that is, polarization to the M2 phenotype, and begin producing various inflammatory mediators, including TNF- , IL-1, and IL-6