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Measurement of lifespan in Drosophila melanogaster

The mechanism involves attraction of immune cells and mesenchymal stem cells to wound sites, along with stimulation of glycosaminoglycan production and decorin synthesis, both of which are critical for proper extracellular matrix assembly

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The study follows a cautious, stepwise dose-escalation approach: starting from the maximum recommended starting dose and moving upward only after a thorough safety review at each level