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[PMC free article: PMC4301911] [PubMed: 25608023] 74

25 In two randomized placebo-controlled trials, totaling 1257 patients with diabetic neuropathy, Sima and colleagues failed to find any significant electrophysiological change in patients treated with 500 or 1,000 mg ALC, although a significant improvement in the vibration perception threshold was reported

According to a recent study (4), any alterations in glutathione metabolic activity can have a profound effect on cell survival

In early-stage cancer and precancerous lesions, decreased expression of GPX3 and increased ROS production stimulate oxidative stress in TME, promoting the progression of EMT and cancer development