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Discussion Colistin is a cyclic heptapeptide with an acylated tripeptide side chain that exerts its antimicrobial activity by disrupting the integrity of the bacterial membrane and increasing its permeability, leading to leakage of the cell content, membrane depolarization and cell death 1

Copper is an essential trace mineral involved in: Collagen synthesis Elastin formation Antioxidant defense Tissue remodeling Blood vessel formation Cellular repair mechanisms GHK-Cu acts as a carrier and signaling peptide that helps regulate tissue repair and cellular communication